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ANKYLOSING SPONDYLITIS
IT IS A CHRONIC GENERALISED INFLAMMATORY DISEASE OF SPINE WITH THE INVOLVEMENT OF PERIPHERAL JOINTS & NON-ARTICULAR SURFACES, MORE COMMON IN MALES.
STRONG ASSOCIATION WITH HLA-B27

SIGNS & SYMPTOMS-
• BACKACHE WORSE IN THE MORNING/ DURING INACTIVITY/ AT NIGHT
• INTERCOSTAL TENDERNESS
• FLATTENING OF LOWER BACK
• DIFFUSE TENDERNESS OF SPINE
• NCREASE THORACIC KYPHOSIS
• GENERALISED OSTEOPOROSIS
• SACROILITIS